U.S. Federal Route 61 runs north-south in De Soto County. It is in the western portion of the county. This runs from the Tunica/De Soto County Line to the Mississippi/Tennessee State Line. U.S. Rt. 61 does not pass through any towns in De Soto County. U.S. Rt. 61 is not multi-plexed in De Soto County. U.S. Rt. 61 intersects the following highways in De Soto County. Mississippi State Route 3, near Newport. Mississppi State Route 302, near Walls.
NB U.S. Rt. 61 near Walls. SB U.S. Rt. 61 at the Mississippi/Tennessee State Line.
