Cast Tobey Maguire Spider-Man/Peter Parker Kirsten Dunst Mary Jane Watson James Franco Harry Osborn Alfred Molina Doc Ock/Dr. Otto Octavius Rosemary Harris May Parker J.K. Simmons J. Jonah Jameson Donna Murphy Rosalie Octavius Daniel Gillies John Jameson Dylan Baker Dr. Curt Connors Bill Nunn Joseph 'Robbie' Robertson Vanessa Ferlito Louise Aasif Mandvi Mr. Aziz Willem Dafoe Green Goblin/Norman Osborn Cliff Robertson Ben Parker Ted Raimi Hoffman Director: Sam Raimi Producer: Laura Ziskin Avi Arad Screenwriter: Alvin Sargent Michael Chabon Steve Ditko Cinematographer: Bill Pope Composer: Danny Elfman Executive Producer: Joseph M. Caracciolo Jr. Stan Lee Story: Michael Chabon Visual Effects: Anthony LaMolinara John Dykstra John Frazier Scott Stokdyk
Peter Parker finds that being Spider-man has caused him nothing but problems, and this emotional turmoil causes him to suddenly lose his powers from time to time and the love of his life, Mary Jane Watson, becomes engaged to John Jameson. His best friend, Harry Osborne also wants Spider-man dead. Peter decides to put Spider-man behind him and try to lead a normal life.
However, a freak accident during a fusion experiment causes Dr. Otto Octavius to become Dr. Octopus, a super-villain with 4 metal tentacles and Spider-man is needed to stop "Doc Ock" before he can destroy the city. Mary Jane Watson finds herself in the middle of things again!