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Illinois 106 is an east-west route in west-central Illinois, running from near Hannibal, MO to US67 south of Jacksonville.

Intersections from west to east:

I-72/US36 near Hannibal, MO

IL96 joins from the north near Hull

Then IL96 breaks off toward the south at Kinderhook

It joins US54 eastbound into Pittsfield

Then US54 leaves to the north in Pittsfield

IL100 joins from the south at Detroit

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Soon after, IL100 leaves to go north on the east side of the Illinois River

IL106 turns south to end at US67 in White Hall.

It passes through these towns: Hull, Kinderhook, Barry, Pittsfield, Detroit, Florence, Winchester, Alsey, White Hall.

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