Intersections from west to east:

US150 joins IL78 south near Laura

Then IL78 splits off while another road splits off to an interchange with I-74

IL91 at Peoria

IL6 shortly after, in Peoria

IL40 in Peoria

US150 crosses IL29, as US24 comes from the south on IL29 and joins US150 east, in Peoria

US24 crosses IL116, as US150 turns southerly onto IL116, which comes from the east (forming a "wrong-way multiplex."

US150 has another interchange with I-74 in East Peoria

US150 breaks off of IL116, as IL8 comes from the west and joins US150 east in East Peoria

IL8 breaks off of US150

It passes through these towns: Kickapoo, Peoria, East Peoria, Morton, and Deer Creek.