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ICUS E-JOURNAL VOL. 001 ISSUE 001
Salicylates Salicylates, are natural chemical compounds found in all plants. They are part of a plant's defense system against pests and have been used as a natural preservative. Originating from willow bark, aspirin is converted into salicylic acid in the human body. In fact, recent studies which have linked aspirin's healthy benefits to the heart and the colon suggest the reason a diet rich in fruit and vegetables is healthy is partly due to the presence of salicylates. However, some people are reactive to salicylates and this can be the cause of hives or urticaria for some people. Dr. Harry Roth of the University of California at San Francisco has his patients try a salicylate free diet for two weeks to see if this improves their condition. To read about Dr. Harry Roth's checklist of causes of urticaria got to: To read more information about salicylates and the origin of aspirin, click here: http://www.ansci.cornell.edu/courses/as625/1997term/Sara/salicy.htm#background Allergol Immunopathol (Madr) 1999 Mar-Apr;27(2):73-85 [Round Table: Urticaria in relation to infections]. [Article in Spanish] Bilbao A, Garcia JM, Pocheville I, Gutierrez C, Corral JM, Samper A, Rubio G, Benito J, Villas P, Fernandez D, Pijoan JI Hospital de Cruces, Vizcaya, Espana. OBJECTIVES: 1) To study the clinical and analytic features of infectious disease associated to urticaria in children. 2) To look into the probable etiology of the infectious disease. 3) To determine atopic predisposition and previous urticarial episodes and to rule out the involvement of antibiotics. DESIGN: Transversal and observational study. SETTING: Pediatric Allergy Outpatient Clinic of a tertiary Hospital. PATIENTS: Forty-four children, aged 1 to 12 years with acute urticaria associated to clinically infectious or febrile illness attending an Emergency Pediatric Department. INTERVENTION: Symptoms evaluation and physical examination in the seventh first days and follow over 3-6 weeks by the same physician. MEASUREMENTS: Clinical features of urticaria (duration, angioedema associated); Clinic diagnosis of illness infectious (acute respiratory infection, gastroenteritis, febrile syndrome); white blood cells count, C-reactive protein, aminotransferases (AST, ALT), L-Y-glutamyl transferase; viral culture and antigen detection: enterovirus (EV), adenovirus, respiratory syncytial virus (RSV), parainfluenza 1, 2 and 3, influenza A y B and cytomegalovirus (CMV); serological assay: CMV, enterovirus, mycoplasma pneumoniae, Epstein-Barr, parvovirus B19. RESULT: 22 children (50%) are between 1-2 years old. 40 patients (90,9%) had symptoms of respiratory tract infection and only four patients had a pneumonia. The other 4 children had a gastroenteritis. The analytic was suggestive of viral infection in 35 (79.5%) and unknown on seven patients. In 20 children (45.4%) was identified a probable infection. The viral detection was positive in 3 patients: CMV, herpes simplex 1 and influenza A. Twenty microbiological findings for seventeen patients was found by serological criterion of probable infection: enterovirus (10); parvovirus B19 (4); Epstein-Barr (3) y mycoplasma (3). Evidence of a double serologic infection was found in three patients. In comparison with a serological control group encountered that acute urticaria during a infectious disease is significantly associated (p = 0.0054) to high titer to enterovirus by complement-fixation. The urticaria was associated with angioedema in 38.6% and 9 children (20.4%) related an previous similar episode. Twenty-one (47.7%) had been treated with antibiotics before development the urticaria. All patients was given the suspected antibiotic and no patient developed any adverse reaction. CONCLUSIONS: The clinically infectious associated to urticarial rash in children, usually is a viral respiratory infections. Is more frequent at infant. In spite of antibiotic therapy is often related to development the urticaria, the subsequent challenge with the same antibiotic is good tolerated. PMID: 10354011, UI: 99282126 Human parvovirus infection: rheumatic manifestations, angioedema, C1 esterase inhibitor deficiency, ANA positivity, and possible onset of systemic lupus erythematosus. Fawaz-Estrup F Division of Rheumatology, Memorial Hospital of Rhode Island, Providence, USA. OBJECTIVE: To investigate the clinical and serological characteristics of parvovirus infection. METHODS: Case series: during 1993-4, 9 adult patients presented with polyarthralgias/polyarthritis. Clinical evaluation and serological studies of antinuclear antibodies, rheumatoid factor (RF), IgM and IgG antibodies to human parvovirus were done in all patients. Other serologies including anti-DNA, serum complement, and C1 esterase inhibitor levels were obtained in some patients. RESULTS: All 9 patients had polyarthralgias/polyarthritis, serological evidence of parvovirus B19 IgM and IgG antibodies, and normal sedimentation rate. All patients were seronegative for RF. Four women had positive ANA titers. In 2 of them the ANA positivity was transient. One developed systemic lupus erythematosus (SLE). Three women had angioedema of the face and tongue; one had transient C1 esterase inhibitor deficiency and another a transient decrease in C4 levels. CONCLUSION: Parvovirus may be implicated in the development of SLE as well as other chronic arthropathies. This is the first reported case of angioedema and decreased C1 esterase inhibitor levels associated with parvovirus infection. PMID: 8823689, UI: 96420992
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