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In this prospective, controlled, pilot, proof-of-principle study, 19 consecutive patients with mild to severe cystic, inflammatory, or comedonal and of the face were enrolled. Each patient was graded regarding the type and severity of the acne (Table 1). Two patients had investigation; inflammatory and comedonal acne and 1 patient had both inflammatory and cystic acne. Patients were aged 16 to 47 years with Fitzpatrick skin types I to VI (including black skin). Patients had no comorbidities and were representative of patients seen in a typical dermatology practice. All 19 patients had failed conventional treatments--topical antibiotics, benzoyl peroxide, or retinoids; oral antibiotics, contraceptives, or isotretinoin; or laser procedures (1450 and diode, Smoothbeam[TM] [Candela Laser Corporation] and light, blue Clearlight[TM] [Lumenis Report Of Foreign Bank Accounts Ltd.]). The treatment options were reviewed extensively with each patient, including topical medications, oral antibiotics, and if applicable oral contraceptives; laser treatments, .
Including blue light and diode (Smoothbeam) laser; acne oral isotretinoin, in addition to the treatment option under both and verbal nm written informed consent was obtained. During .
The verbal and written informed consent, it was indicated that LP PDL and LP PDL-mediated PDT were not FDA-approved for the treatment of acne vulgaris, but were off-label applications of these therapeutic modalities and experimental.
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