U.S. Federal Route 150 runs north-south in the north-central portion of Knox County. At Vincennes this highway turns and runs east-west. U.S. Rt. 150 does not pass through any towns in Knox County. U.S. Rt. 150 is multi-plexed in Knox County. U.S. Rt. 41, from the Knox/Sullivan County Line to east of Vincennes. U.S. Rt. 50, from north of Vincennes to the Knox/Daviess County Line. U.S. Rt. 150 intersects the following highways in Knox County. Indiana State Route 67, near Bruceville. U.S. Rt. 50, north of Vincennes. U.S. Rt. 41, east of Vincennes. U.S. Rt. 50, east of Vincennes.