U.S. Rt. 41 runs north south along the western portion of Knox County. This is a four-lane divided route through the entire county. U.S. Rt. 41 does not pass through any towns in Knox County. U.S. Rt. 41 is multi-plexed in Knox County. U.S. Rt. 150, from the Knox/Sullivan County Line to just east of Vincennes. U.S. Rt. 50, around Vincennes. U.S. Rt. 41 crosses the following highways in Knox County. Indiana State Route 550, near Emison. Indiana State Route 67, near Bruceville. U.S. Rt. 50, on the northside of Vincennes. U.S. Rt. 150, on the eastside of Vincennes. U.S. Rt. 50, on the eastside of Vincennes.