U.S. Rt. 50 is the main east-west highway across Knox County. This remains four-lanes through the entire county. U.S. Rt. 50 does not pass through any town in Knox County. U.S. Rt. 50 is multi-plexed in Knox County. U.S. Rt. 41, around Vincennes. U.S. Rt. 150, from the northside of Vincennes to the Knox/Daviess County Line. U.S. Rt. 50 intersects the following highways in Knox County. U.S. Rt. 41, on the northside of Vincennes. U.S. Rt. 150, on the northside of Vincennes. U.S. Rt. 41, on the eastside of Vincennes.
EB U.S. Rt. 50 at the Illinois/Indiana State Line. This is the Wabash River bridge. The Indiana welcome sign. BGS for the exits to access the City of Vincennes. Note that these are for U.S. Rt. 41. That is because U.S. Rt. 41 by-passes the most of the city. EB U.S. Rt. 50 at U.S. Rt. 41/150. EB U.S. Rt. 50 at U.S. Rt.41/150 on the northside of Vincennes. EB U.S. Rt. 50/150; at SB U.S. Rt. 41 on the eastside of Vincennes.
