U.S. Federal Route 18 runs east-west across Northern and Central Floyd County. From the Cerro Gordo/Floyd County Line to near Charles City, this runs along the Avenue of Saints corridor. It is a multi-lane highway, with speeds near a posted 65 M.P.H. U.S. Rt. 18 passes through the following town in Floyd County. Charles City U.S. Rt. 18 is multi-plexed in Floyd County. Iowa State Route 27, from the Cerro Gordo/Floyd County Line to near Charles City.
U.S. Rt. 218, from near Floyd to near Charles City.
U.S. Rt. 18 intersects the following highways in Floyd County. U.S. Rt. 218, near Floyd.