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Intersections from north to south:

I-80 near Frankfort

US30 at Frankfort

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US52 comes from the east near Manhattan and joins US45 south

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IL102 at Bourbonnais IL17 joins from the west at Kankakee

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IL17 splits off to continue eastward in downtown Kankakee

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IL115 in Kankakee

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IL50 in Kankakee

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In rural Iroquois County, US45 turns westerly, US52 splits off to continue east as IL49 begins and heads south

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IL116 begins as US45 turns southerly again, at Ashkum

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US45 joins US24 west at Gilman

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US45 splits off of US24 a few miles after joining

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IL54 at Onarga IL9 at Paxton

It passes through these towns: Frankfort, Bourbonnais, Bradley, Kankakee, Ashkum, Danforth, Gilman, Onarga, Buckley, Loda, and Paxton.

Continue north- Cook/Will County line to Wisconsin State line

Continue south- Ford/Champaign County line to Douglas/Coles County line

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