Within Peter Parker's body, Doctor Octopus starts his new career as a hero by redesigning his gear and putting his past as a villain behind himself.[58] However, he soon finds himself the target of several villains, such as an Octavius-tech enhanced Stilt-Man, Boomerang, Overdrive, Shocker, Speed Demon, the unnamed female Beetle, Living Brain, and all of them trying to take over the place left by the seemingly dead Otto Octavius and his Sinister Six. While they're still no match for the new, more ruthless Spider-Man, his violence and new mannerisms start to tip off several of his close friends and allies, such as the whole Horizon Labs, Daredevil, Wolverine (who is explicitly forbidden to have Spider-Man's mind telepathically scanned under the threat of legal action in court), Mary Jane and Carlie Cooper.
Despite his accomplishments, Otto Octavius is revealed to be still haunted by the lingering spirit of Peter Parker, unable to reassert control over their shared body, but actively hampering his efforts to stray from Peter's values, and trying to reclaim his body. Despite Peter's lingering influence, Octavius' refusal of Peter's values and perceived screw-ups prompts him to "rectify" some mistakes: the "new" Peter enrolls back to college, pursuing actively the PhD Peter denied himself in the past, and breaks the self-imposed "no-kill rule" by taking a proactive stance against evildoers and criminals, shooting the villain Massacre even after Massacre appeared to show signs of recovering from the brain damage that motivated his crimes, and violently assaulting a couple of villains for a relatively minor insult. These actions prompted the Avengers to confront 'Spider-Man' about his recent activities, recognizing that their friend would never act in such a manner.
"Hero":
Spider-Man
Supporting Cast:
Mary Jane Watson
Carlie Cooper
Mayor J. Jonah Jameson
Anna Marconi
The Living Brain
Horizon Labs
Empire State University
Allies:
The Spiderlings
The Avengers
The Superior Six
Spider-Man 2099
Equipment:
Spider-Island II
The Arach-Nauts
Villains:
The Green Goblin
Stilt-Man
The Vulture
Massacre
Electro
Screwball
The Jester
Cardiac
Spider-Slayer
The Scorpion
The Kingpin of Crime
The Hobgoblin
Stunner
Menace
Goblin Knight
Monster
Villainous Groups:
The Goblin Army
The Sinister Six