Illinois 21 is a north-south route running through Chicago's northern suburbs. It runs along Milwaukee Avenue.

Intersections from south to north (from Chicago outbound):

IL21 begins at IL43 at Niles

IL58 by Des Plaines

IL21 joins US45 north near Wheeling

IL68 at Wheeling

IL22 near Lincolnshire

US45 breaks off soon after

IL60 near Vernon Hills

IL176 at Libertyville

IL137

IL120

IL132 at Gurnee

IL21 ends at US41 near Gurnee.

It passes through these towns: Niles, Des Plaines, Prospect Heights, Wheeling, Vernon Hills, Libertyville, and Gurnee.

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