Intersections from north to south:
US45 enters the state of Illinois from the Wisconsin side of the border in north-central Lake County
IL132 near Lindenhurst
IL120 near Grayslake
US45 crosses IL60
Very shortly after, it meets and "bounces off" IL83 near Vernon Hills
At Lincolnshire, US45 joins IL21 south
Very shortly after that, US45/IL21 crosses IL22
IL68 at Wheeling
IL21 splits off of US45 near Prospect Heights
IL58 at Des Plaines
US12 joins from the northwest at Des Plaines
US14 at downtown Des Plaines
IL72 by O'Hare Airport
I-190 by O'Hare Airport
IL19 at Schiller Park
IL64 near Melrose Park and Northlake
US20 joins from the west, forming a "tripleplex" (US12/20/45)
IL56 at Bellwood
I-290 at Westchester
IL38 at Westchester
US34 at La Grange
I-55 near Justice
IL171 at Justice
US12 and US20 finally break off of US45 to head easterly together at Hickory Hills
IL83 near Palos Heights
IL7 near Orland Park
US6 at Orland Park
It passes through these towns: Lindenhurst, Mundelein, Vernon Hills, Wheeling, Des Plaines, Bellwood, Westchester, La Grange, Countryside, Hodgkins, Justice, Palos Park, and Orland Park.
Continue south- Cook/Will County line to Ford/Champaign County line
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