After a mysterious Pulse hit the Earth, it affected technology worldwide, left strange energy signatures, and traces of an unknown material. After this unknown material was researched by S.H.I.E.L.D., and being called "Isotope-8", it was discovered it was the source of a form of energy that, uncontrolled can be lethal, but worked in the good way could bring the one who has it an unimaginable power.
Nick Fury told an agent of S.H.I.E.L.D. to make a team with the most powerful superheroes on Earth to collect all the Iso-8 before villains could get their hands on it, for that, the supervillains made their own alliance a Syndicate led by Doctor Doom.
The Alliance had worked on different missions no related with the Iso-8, such as Mephisto's arrival on Earth.
Leader:
Typical S.H.I.E.L.D. Agent
Members:
Iron Man
Black Widow
Hawkeye
Black Cat
Captain America
Colossus
Cyclops
Daredevil
Doctor Strange
The Hulk
Human Torch
Invisible Woman
Iron Fist
Kitty Pryde
Luke Cage
Mr. Fantastic
Ms. Marvel
Nightcrawler
Phoenix
She-Hulk
Sif
Spider-Man
Spider-Woman
Storm
The Thing
Thor
War Machine
Wolverine
Mockingbird
Black Panther
Scarlet Witch
Emma Frost
Rogue
Gambit
Magik
Quicksilver
Deadpool
Hercules
Ghost Rider
Beast
Cable
Valkyrie
Tigra
Psylocke
The Punisher
Havok
Magneto
X-23
Wasp
Captain Britain
Hank Pym
Fantomex
Black Knight
Vision
Omega Sentinel
Shatterstar
Union Jack
Rescue
Red Hulk
The Juggernaut
Thundra
Wonder Man
The Constrictor
Angel
Daimon Hellstrom
Satana
Bishop
Elektra
Ares
Squirrel Girl
Black Bolt
Thane
Spiral
Moon Knight
Heimdall
Loki
Doctor Voodoo
Domino
Sabretooth
Doctor Doom
Nico Minoru
Moonstone
Agent Venom
Sunfire
Iceman
Hogun
Fandrall
Volstagg
Falcon
The Taskmaster
Rocket Raccoon
Gamora
Sandman
Anti-Venom
Shanna the She-Devil
Drax the Destroyer
Cannonball
Avalanche
Groot
Star-Lord
Medusa
Ka-Zar and Zabu
Kang the Conqueror
Gorgon
Blade
Morbius
Karnak
The Fixer
Molly Hayes
Hybrid
Crystal
Nova
Karolina Dean
Beta Ray Bill
The Enchantress
Angela
The Destroyer
Chase Stein
Victor Mancha
Deathlok
Kate Bishop
Ultimate Spider-Man
Superior Spider-Man
Spider-Man Noir
Ant-Man
Quake
Spider-Girl
Hyperion
Spider-Gwen
Spider-Man 2099
Blizzard
Silk
Amazing Spider-Woman
A-Bomb
Baron Mordo
Spitfire
Misty Knight
Kamala Khan and Lockjaw
Elsa Bloodstone
Jessica Jones
Boomerang
Colleen Wing
Howard the Duck
Red She-Hulk
Winter Soldier
Kraven the Hunter
The Lizard
Hellcat
Electro
Cammi
Cloak and Dagger
The Shocker
Death Locket
Thor (Jane Foster)
Blue Marvel
The Beetle
Mantis
Moondragon
Richard Rider
Knight America
Faiza Hussain
Songbird
Ronan the Accuser
Phyla-Vell
White Tiger
Adam Warlock
Supporting Cast:
Nick Fury
Maria Hill
Phil Coulson
Professor X
Agent Abigail Brand
Cosmo
Allied Groups:
The Avengers
The X-Men
The Fantastic Four
Excaliber
The Guardians of the Galaxy
The Inhumans
The Spider-Army
